The following is Lufthansa’s Inter-Continental Network from Summer 2000, taken from OAG – Worldwide Edition – Aug 2000.
| Route |
Freq (Wk) & A/C |
Remark |
| Frankfurt – Alexandria | 5 32S | |
| Frankfurt – Almaty | 5 AB3 | |
| Frankfurt – Amman | 7 32S | |
| Frankfurt – Atlanta | 7 340 | |
| Frankfurt – Baku – Ashgabat | 3 AB6 | |
| Frankfurt – Bangkok | 3 744 | |
| Frankfurt – Bangkok – Ho Chi Minh | 2 744 | |
| Frankfurt – Bangkok – Manila | 2 744 | |
| Frankfurt – Beijing | 7 744 | |
| Frankfurt – Beirut | 5 32S | |
| Frankfurt – Bogota | 3 340 | |
| Frankfurt – Boston | 7 747 3 340 |
|
| Frankfurt – Buenos Aires – Santiago de Chile | 6 744 | |
| Frankfurt – Cairo | 3 340 | |
| Frankfurt – Cairo – Addis Ababa | 4 340 | |
| Frankfurt – Cairo – Asmara | 1 AB3 | |
| Frankfurt – Cairo – Khartoum | 3 AB3 | |
| Frankfurt – Cairo – Sana’a | 3 AB3 | |
| Frankfurt – Caracas | 3 340 | |
| Frankfurt – Casablanca | 4 32S | |
| Frankfurt – Chennai | 3 744 | |
| Frankfurt – Chicago | 7 747 7 340 |
|
| Frankfurt – Dallas | 7 340 | |
| Frankfurt – Delhi | 7 747 | |
| Frankfurt – Detroit | 7 340 | |
| Frankfurt – Dubai – Abu Dhabi | 7 340 | |
| Frankfurt – Ekaterinburg | 1 32S | |
| Frankfurt – Ekaterinburg – Perm | 2 32S | |
| Frankfurt – Hong Kong | 7 744 3 340 |
|
| Frankfurt – Houston | 7 340 | |
| Frankfurt – Jeddah – Asmara | 3 AB6 | |
| Frankfurt – Johannesburg – Cape Town | 7 744 | |
| Frankfurt – Kuwait – Muscat | 3 AB6 | |
| Frankfurt – Lagos | 2 340 | |
| Frankfurt – Lagos – Accra | 2 340 | |
| Frankfurt – Los Angeles | 14 744 | |
| Frankfurt – Manila | 5 744 | |
| Frankfurt – Mexico City | 7 744 | |
| Frankfurt – Miami | 7 747 | |
| Frankfurt – Mumbai | 7 747 | |
| Frankfurt – Nagoya | 3 340 | |
| Frankfurt – Newark | 7 747 | |
| Frankfurt – New York JFK | 9 747 5 744 6 340 |
|
| Frankfurt – Nizhniy Novgorod | 2 32S | |
| Frankfurt – Osaka | 7 747 | |
| Frankfurt – Philadelphia | 7 340 | |
| Frankfurt – Rio de Janeiro | 3 340 | |
| Frankfurt – Riyadh – Dammam | 3 340 | |
| Frankfurt – Samara | 1 32S | |
| Frankfurt – Samara – Kazan | 2 32S | |
| Frankfurt – San Francisco | 7 747 | |
| Frankfurt – Sao Paulo | 7 340 | |
| Frankfurt – Seoul | 7 340 | |
| Frankfurt – Shanghai | 6 747 | |
| Frankfurt – Singapore | 3 340 | |
| Frankfurt – Singapore – Jakarta | 7 744 | |
| Frankfurt – Tashkent | 3 AB6 | |
| Frankfurt – Tehran | 3 AB6 | |
| Frankfurt – Tel Aviv | 7 340 7 32S |
|
| Frankfurt – Tokyo | 10 744 | |
| Frankfurt – Toronto | 7 744 | |
| Frankfurt – Tripoli | 4 32S | |
| Frankfurt – Tunis | 3 737 2 32S |
|
| Frankfurt – Vancouver | 7 747 | |
| Frankfurt – Washington | 7 744 7 340 |
|
| Frankfurt – Windhoek – Harare | 3 340 | |
| Munich – Cairo | 1 32S | |
| Munich – Chicago | 7 340 | |
| Munich – Newark | 7 340 | |
| Munich – San Francisco | 7 744 | |
| Munich – Tel Aviv | 3 32S | |
| Dusseldorf – Newark | 7 340 |